2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171578
    3′-Amino-2′,3′-dideoxy-CTP
    3′-Amino-2′,3′-dideoxy-CTP is an analogue of nucleoside triphosphate. 3′-Amino-2′,3′-dideoxy-CTP can selectively inhibit DNA polymerase β.
    3′-Amino-2′,3′-dideoxy-CTP
  • HY-W393243R
    3′-O-Methyladenosine (Standard)
    (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (Adenosine, 3'-O-methyl- (8CI)(9CI)) is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3′-O-Methyladenosine (Standard)
  • HY-171526
    2′-F-UDP
    2′-F-UDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-F-UDP
  • HY-W048245
    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol
    		98.74%
    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol
  • HY-131773
    2-Cl-5'-AMP
    2-Cl-5'-AMP is a 5'-AMP analogue and can be used for receptor mapping research.
    2-Cl-5'-AMP
  • HY-137701A
    ddATPαS tetrasodium
    ddATPαS tetrasodium is a dideoxynucleotide that can be used for DNA sequencing.
    ddATPαS tetrasodium
  • HY-157093
    Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate)
    Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide.
    Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate)
  • HY-W113609
    5-Phenyluracil
    5-Phenyluracil is a thymidine phosphorylase inhibitor.
    5-Phenyluracil
  • HY-B0116A
    Stavudine sodium
    Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.
    Stavudine sodium
  • HY-13548
    DL-Alanosine
    		Inhibitor
    DL-Alanosine is an amino acid analogue with antitumor activities.
    DL-Alanosine
  • HY-126160
    CB10-277
    CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma.
    CB10-277
  • HY-W700549
    DMT-dT
    DMT-dT is a nucleotide derivative.
    DMT-dT
  • HY-W014306R
    2',3'-Dideoxyuridine (Standard)
    2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3'-Dideoxyuridine (Standard)
  • HY-129972
    Ribavirin 5'-monophosphate dilithium
    Ribavirin 5'-monophosphate dilithium is an active form of ribavirin that inhibits IMP dehydrogenase, and ribavirin itself is a broad-spectrum antiviral agent.
    Ribavirin 5'-monophosphate dilithium
  • HY-B1468R
    8-Azaguanine (Standard)
    		Chemical
    8-Azaguanine (Standard) is the analytical standard of 8-Azaguanine. This product is intended for research and analytical applications. 8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.
    8-Azaguanine (Standard)
  • HY-W590551A
    Adenosine 5′-O-(1-thiotriphosphate) disodium
    Adenosine 5′-O-(1-thiotriphosphate) (disodium) is an α-Phosphate modified adenosine nucleotide.
    Adenosine 5′-O-(1-thiotriphosphate) disodium
  • HY-114247
    FMAU
    		98.66%
    FMAU is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    FMAU
  • HY-17400R
    Tegafur (Standard)
    		Inhibitor
    Tegafur (Standard) is the analytical standard of Tegafur. This product is intended for research and analytical applications. Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil.
    Tegafur (Standard)
  • HY-W098689
    Dmf-dg
    		≥98.0%
    Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a deoxyguanosine (dG) nucleoside protected by the dimethylaminomethylamidine (DMF) base and can be used for oligonucleotide synthesis.
    Dmf-dg
  • HY-134991A
    3'-Deoxy-GTP trisodium
    3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP trisodium inhibits DENV NS5 RdRp (IC50: 0.02 μM).
    3'-Deoxy-GTP trisodium